Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice.
Identifieur interne : 000A23 ( Main/Exploration ); précédent : 000A22; suivant : 000A24Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice.
Auteurs : Jianzhong Shi [République populaire de Chine] ; Zhiyuan Wen ; Jing Guo ; Ying Zhang ; Guohua Deng ; Yuelong Shu ; Dayan Wang ; Yongping Jiang ; Yoshihiro Kawaoka [États-Unis] ; Zhigao Bu ; Hualan ChenSource :
- Antiviral research [ 1872-9096 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Chine (épidémiologie), Femelle, Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Lymphocytes T CD4+ (immunologie), Saisons, Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H1N1 du virus de la grippe A (physiologie), Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (physiologie), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- génétique : Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A.
- immunologie : Anticorps antiviraux, Grippe humaine, Lymphocytes T CD4+, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux.
- physiologie : Sous-type H1N1 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A.
- épidémiologie : Chine, Grippe humaine.
- Animaux, Femelle, Grippe humaine, Humains, Saisons, Souris, Souris de lignée BALB C.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (immunology), CD4-Positive T-Lymphocytes (immunology), China (epidemiology), Female, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N1 Subtype (physiology), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (physiology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Mice, Mice, Inbred BALB C, Seasons.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , immunology : Antibodies, Viral, Influenza Vaccines.
- geographic , epidemiology : China.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype.
- immunology : CD4-Positive T-Lymphocytes, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza, Human.
- physiology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype.
- prevention & control : Influenza, Human.
- Animals, Female, Humans, Mice, Mice, Inbred BALB C, Seasons.
Abstract
Vaccination is a key strategy for preventing influenza virus infections. Here, we generated a reassortant virus (SC/AAca) containing the hemagglutinin and neuraminidase genes from a 2009 pandemic influenza virus A/Sichuan/1/2009 (H1N1) (SC/09) and six internal genes from the cold-adapted virus A/Ann Arbor/6/60 (H2N2) (AAca). The SC/AAca reassortant induced a sound humoral immune response and complete protection against homologous SC/09 virus challenge in mice after intranasal administration of an at least 10(6) 50% egg infectious dose (EID(50)) of SC/AAca. SC/AAca inoculation also induced significant CD4+ and CD8+ T cell responses and provided solid protection against heterologous H1N1 and H5N1 virus challenge. Our results suggest that this 2009 H1N1 live vaccine will provide protection against both 2009 pandemic and seasonal H1N1 virus infection and might reduce the severity of H5N1 virus infection in humans. The induction of cross-reactive virus-specific T cell responses may be an effective approach to develop universal influenza vaccines.
DOI: 10.1016/j.antiviral.2012.01.001
PubMed: 22281419
Affiliations:
- République populaire de Chine, États-Unis
- Wisconsin
- Madison (Wisconsin)
- Université du Wisconsin à Madison
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000151
- to stream PubMed, to step Curation: 000151
- to stream PubMed, to step Checkpoint: 000126
- to stream Ncbi, to step Merge: 000737
- to stream Ncbi, to step Curation: 000737
- to stream Ncbi, to step Checkpoint: 000737
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Le document en format XML
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is a key strategy for preventing influenza virus infections. Here, we generated a reassortant virus (SC/AAca) containing the hemagglutinin and neuraminidase genes from a 2009 pandemic influenza virus A/Sichuan/1/2009 (H1N1) (SC/09) and six internal genes from the cold-adapted virus A/Ann Arbor/6/60 (H2N2) (AAca). The SC/AAca reassortant induced a sound humoral immune response and complete protection against homologous SC/09 virus challenge in mice after intranasal administration of an at least 10(6) 50% egg infectious dose (EID(50)) of SC/AAca. SC/AAca inoculation also induced significant CD4+ and CD8+ T cell responses and provided solid protection against heterologous H1N1 and H5N1 virus challenge. Our results suggest that this 2009 H1N1 live vaccine will provide protection against both 2009 pandemic and seasonal H1N1 virus infection and might reduce the severity of H5N1 virus infection in humans. The induction of cross-reactive virus-specific T cell responses may be an effective approach to develop universal influenza vaccines.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Wisconsin</li></region><settlement><li>Madison (Wisconsin)</li></settlement><orgName><li>Université du Wisconsin à Madison</li></orgName></list><tree><noCountry><name sortKey="Bu, Zhigao" sort="Bu, Zhigao" uniqKey="Bu Z" first="Zhigao" last="Bu">Zhigao Bu</name><name sortKey="Chen, Hualan" sort="Chen, Hualan" uniqKey="Chen H" first="Hualan" last="Chen">Hualan Chen</name><name sortKey="Deng, Guohua" sort="Deng, Guohua" uniqKey="Deng G" first="Guohua" last="Deng">Guohua Deng</name><name sortKey="Guo, Jing" sort="Guo, Jing" uniqKey="Guo J" first="Jing" last="Guo">Jing Guo</name><name sortKey="Jiang, Yongping" sort="Jiang, Yongping" uniqKey="Jiang Y" first="Yongping" last="Jiang">Yongping Jiang</name><name sortKey="Shu, Yuelong" sort="Shu, Yuelong" uniqKey="Shu Y" first="Yuelong" last="Shu">Yuelong Shu</name><name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name><name sortKey="Wen, Zhiyuan" sort="Wen, Zhiyuan" uniqKey="Wen Z" first="Zhiyuan" last="Wen">Zhiyuan Wen</name><name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Shi, Jianzhong" sort="Shi, Jianzhong" uniqKey="Shi J" first="Jianzhong" last="Shi">Jianzhong Shi</name></noRegion></country><country name="États-Unis"><region name="Wisconsin"><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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